Prof. Dr. med. Elke Raum, MPH

• Medical and nursing service provision
• Social Medicine 
• Case studies in health care management
• Public Health
• Health economic evaluation
• Qualitative and quantitative social research
• Health services research
• Patient-oriented medical care

• Public Health
• Epidemiology of chronic diseases
• Health services research
• Workplace health promotion

• Head of degree program B.Sc Health Economics in the Practice Network
• Program Director M.Sc. Health Care Management - Health Care Management
• Member of the faculty council

• German Society for Epidemiology

• Nowack R, Raum E, Blum W, Ritz E. Renal hemodynamics in recent-onset type II diabetes. Am J Kidney Dis 1992, 20: 342 - 7.
• RaumE, Seidler A, Schlaud M, Knoll A, Weßling H, Kurtz K, Schwartz FW, Robra B-P. Contamination of human breast milk with organochlorine residues: a comparison between East and West Germany through sentinel practice networks. J Epidemiol Community Health 1998; 52: 50S - 55S.
• Seidler A, Schlaud M, Raum E, Schwartz FW. Predictors of progression of asthmatic symptoms in early childhood - results of a follow-up study. Clin Pediatrics 1998, 210: 24 - 29.
• Seidler A, Raum E, Arabin B, Hellenbrandt W, Walter U, Schwartz FW. Maternal occupational exposure to chemical substances and the risk of infants small for gestational age. Am J Ind Med 1999; 36: 213 - 222.
• Schlaud M, Haase I, Hoopmann M, Kurtz C, Listing L, Raum E, Seidler A, Weßling A, Brandstädter W, Robra B-P, Schwartz FW. The observational practice in Saxony-Anhalt - An overview of the MORBUS-A project. Ärzteblatt Sachsen-Anhalt 1999; 10:46 - 49.
• Arabin B, Raum E, Mohnhaupt A, Schwartz FW. Two types of health care systems and their influence on the introduction of perinatal care: an epidemiological twin model in Berlin from 1950 up to 1990. Maternal and Child Health Journal 1999, 3: 81 - 91.
• Jendro MC, Deutsch T, Körber B, Köhler L, Kuipers LG, Krausse-Opatz B, Westermann J, Raum E, Zeidler H. Infection of Human Monocyte-Derived Macrophages with Chlamydia trachomatis Induces Apoptosis of T Cells: a Potential Mechanism for Persistent Infection. Infect. Immun. 2000. 68:6704-6711.
• Raum E, Arabin B, Schlaud M, Walter U, Schwartz FW. The impact of maternal education on intrauterine growth: a comparison of former West and East Germany. Int J Epidemiol 2001; 30: 81 - 87.
• Jendro MC, Fingerle F, Deutsch T, Liese A, Kohler L, Kuipers JG, Raum E, Martin M, Zeidler H. Chlamydia trachomatis-infected macrophages induce apoptosis of activated T cells by secretion of tumor necrosis factor-alpha in vitro. Med Microbiol Immunol 2004; 193: 45 - 53.
• Jendro MC, Raum E, Schnarr S, Kohler L, Zeidler H, Kuipers JG, Martin M. Cytokine profile in serum and synovial fluid of arthritis patients resembling Chlamydia trachomatis infection. Rheumatol Int 2005; 25: 37 - 41.
• Wagner AD, Andresen J, Raum E, Lotz J, Zeidler H, Kuipers JG, Jendro MC. Standardised work-up programme for fever of unknown origin and contribution of magnetic resonance imaging for the diagnosis of hidden systemic vasculitis. Ann Rheum Dis 2005; 64: 105 - 110.
• Sturmer T, Raum E, Buchner M, Gebhardt K, Schiltenwolf M, Richter W, Brenner H. Pain and high sensitivity C reactive protein in patients with chronic low back pain and acute sciatic pain. Ann Rheum Dis 2005; 64: 921 - 925.
• Gebhardt K, Brenner H, Sturmer T, Raum E, Richter W, Schiltenwolf M, Buchner M. The course of high-sensitive C-reactive protein in correlation with pain and clinical function in patients with acute lumbosciatic pain and chronic back pain - a 6 months prospective longitudinal study. Eur J Pain 2006; 10: 711 - 719.
• E. Raum, D. Rothenbacher, C. Stegmaier, H. Ziegler, H. Brenner. Five years of ESTHER study in Saarland - a first interim review Saarländisches Ärzteblatt 2006; 59: 45-46.
• Lietzau S, Raum E, von Baum H, Marre R, Brenner H. Clustering of antibiotic resistance of E. coli in couples: suggestion for a major role of conjugal transmission. BMC Infect Dis 2006; 6: 119.
• Raum E, Gebhardt K, Buchner M, Schiltenwolf M, Brenner H. Long-term and short-term consumption and levels of C-reactive protein. Int J Cardiol 2007; 121: 224 - 226.
• Raum E, Rothenbacher D, Ziegler H, Brenner H. Heavy physical activity: risk or protective factor for cardiovascular disease? A life course perspective. Ann Epidemiol 2007; 17: 417 - 424.
• Lietzau S, Raum E, von Baum H, Marre R, Brenner H. Household contacts were key factor for children's colonization with resistant Escherichia coli in community setting. J Clin Epidemiol 2007; 60:1149 - 1155.
• Raum E, Rothenbacher D, Löw M, Stegmaier C, Ziegler H, Brenner H. Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach. Eur J Cardiovas Prev Reha 2007; 14: 809 - 814.
• Hoffmeister M, Raum E, Winter J, Chang-Claude J, Brenner H. Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany. Br J Cancer 2007; 97: 1486 - 1492.
• Raum E, Lietzau S, von Baum H, Marre R, Brenner H. Chances of E. coli resistance patterns during and after antibiotic therapy: a longitudinal study among outpatients in Germany. Clin Microbiol Infect 2008; 14: 41 - 48.
• Raum E, Lietzau S, Stegmaier C, Brenner H, Rothenbacher D. For the majority of patients with diabetes blood pressure and lipid management is not in line with recommendations. Results from a large population-based cohort in Germany Pharmacoepidemiology and Drug Safety 2008; 17: 485 - 494.
• Widschwendter M, Apostolidou S, Raum E, Rothenbacher D, Fiegl H, Menon U, Stegmaier C, Jacobs IJ, Brenner H. Epigenotyping in peripheral blood cell DANN and breast cancer risk: a proof of priniciple study. PLoS ONE 2008; 3: e2656.
• Brenner H, Stegmaier C, Raum E. The ESTHER study: challenges posed by demographic aging in focus. Saarland Medical Journal 2008; 7: 19 - 20.
• Breitling LP, Dahmen N, Mittelstraß K, Illig T, Rujescu D, Raum E, Winterer G, Brenner H. Smoking cessation and variations in nicotinic acetylcholine receptor subunits -5, -3 and -4 genes. Biol Psychiatry 2009; 65: 691 - 695.
• Zhang QL, Koenig W, Raum E, Stegmaier C, Brenner H, Rothenbacher D Epidemiology of chronic kidney disease: results from a population of older adults in Germany. Prev Med 2009; 48: 122 - 127. 
• Müller H, Raum E, Rothenbacher D, Stegmaier C, Brenner H. Association of Diabetes and Body Mass Index with Levels of Prostate-Specific Antigen: Implications for Correction of Prostate-Specific Antigen Cutoff Values? Cancer Epidemiol Biomarkers Prev. 2009; 18: 1350-6.
• Breitling LP, Dahmen N, Mittelstrass K, Rujescu D, Gallinat J, Fehr C, Giegling I, Lamina C, Illig T, Müller H, Raum E, Rothenbacher D, Wichmann HE, Brenner H, Winterer G. Association of nicotinic acetylcholine receptor subunit alpha4 polymorphisms with nicotine dependence in 5500 Germans. Pharmacogenomics J 2009; 9:219-24. 
• Breitling LP, Raum E, Müller H, Rothenbacher D, Brenner H. Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase. Hepatology 2009; 49:802-8.
• Raum E, Gigout F, Stegmaier C, Reichrath J, Brenner H. Vitamin D - underestimated protective shield? Saarland-wide prevention campaign of vitamin D deficiency in the elderly population. Saarland Medical Journal 2009.
• Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Aliment Pharmacol Ther 2009; 30:113-13.
• Breitling LP, Dahmen N, Illig T, Rujescu D, Nitz B, Raum E, Winterer G, Rothenbacher D, Brenner H. Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events. Pharmacogenet Genomics 2009; 19:657-9.
• Widschwendter M, Lichtenberg-Frate H, Hasenbrink G, Schwarzer S, Dawnay A, Lam A, Menon U, Apostolidou S, Raum E, Stegmaier C, Jacobs IJ, Brenner H. Serum oestrogen receptor alpha and beta bioactivity are independently associated with breast cancer: a proof of principle study. Br J Cancer 2009; 101: 160-5.
• Emerging Risk Factors Collaboration, Erqou S, Kaptoge S, Perry PL, Di Angelantonio E, Thompson A, White IR, Marcovina SM, Collins R, Thompson SG, Danesh J. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA. 2009; 302:412-3. * Authors on behalf of the ESTHER study: Brenner H, Raum E, Müller H, Rothenbacher D. 
• Breitling LP, Twardella D, Raum E, Brenner H. Situational temptation scores and smoking cessation in general care. Psychol Addict Behav 2009; 23:362-7.
• Hoffmeister M, Raum E, Krtschil A, Chang-Claude J, Brenner H. No Evidence for Variation in Colorectal Cancer Risk Associated With Different Types of Postmenopausal Hormone Therapy. Clin Pharmacol Ther. 2009; 86:416-24.
• Yin L, Raum E, Haug U, Arndt V, Brenner H Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk. Cancer Epidemiol. 2009;33:435-45. 
• Emerging Risk Factors Collaboration, Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, Thompson A, Wood AM, Lewington S, Sattar N, Packard CJ, Collins R, Thompson SG, Danesh J. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302:1993-2000.
• Breitling LP, Rothenbacher D, Stegmaier C, Raum E, Brenner H. Older smokers' motivation and attempts to quit smoking: epidemiological insight into the question of lifestyle versus addiction. Dtsch Arztebl Int. 2009;106:451-5.
• Mobascher A, Rujescu D, Mittelstraß K, Giegling I, Lamina C, Nitz B, Brenner H, Fehr C, Breitling LP, Gallinat J, Rothenbacher D, Raum E, Müller H, Ruppert A, Hartmann AM, Möller HJ, Gal A, Gieger C, Wichmann HE, Illig T, Dahmen N, Winterer G. Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. Am J Med Genet B Neuropsychiatr Genet. 2010; 153B:684-90.
• Gao L, Weck MN, Raum E, Stegmaier C, Rothenbacher D, Brenner H. Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from Germany. Int J Epidemiol. 2010; 39:129-34.
• Breitling LP, Müller H, Raum E, Rothenbacher D, Brenner H. Low-to-moderate alcohol consumption and smoking cessation rates: retrospective analysis of 4576 elderly ever-smokers. Drug Alcohol Depend. 2010;108:122-9.
• Emerging Risk Factors Collaboration, Kaptoge S, Di Angelantonio E, Lowe G, Pepys MB, Thompson SG, Collins R, Danesh J. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet. 2010;375:132-40.
• Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration, Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt SM, Ouwehand W, Watkins H, Samani NJ, Saleheen D, Lawlor D, Reilly MP, Hingorani AD, Talmud PJ, Danesh J. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet. 2010;375:1634-9.
• Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Meta-analysis: serum vitamin D and breast cancer risk. Eur J Cancer. 2010;46:2196-205.
• Corrieri S, Heider D, Matschinger H, Lehnert T, Raum E, König HH. Income-, education- and gender-related inequalities in out-of-pocket health-care payments for 65+ patients - a systematic review. Int J Equity Health. 2010;9:20.
• Emerging Risk Factors Collaboration, Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio E, Ingelsson E, Lawlor DA, Selvin E, Stampfer M, Stehouwer CD, Lewington S, Pennells L, Thompson A, Sattar N, White IR, Ray KK, Danesh J. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375:2215-22. 
• Chronic Kidney Disease Prognosis Consortium, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010;375:2073-81.
• Winterer G, Mittelstrass K, Giegling I, Lamina C, Fehr C, Brenner H, Breitling LP, Nitz B, Raum E, Müller H, Gallinat J, Gal A, Heim K, Prokisch H, Meitinger T, Hartmann AM, Möller HJ, Gieger C, Wichmann HE, Illig T, Dahmen N, Rujescu D. Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1448-58.
• Breitling LP, Wolf M, Müller H, Raum E, Kliegel M, Brenner H. Large-scale application of a telephone-based test of cognitive functioning in older adults.Dement Geriatr Cogn Disord. 2010;30:309-16. 
• Lochhead P, Frank B, Hold GL, Rabkin CS, Ng MT, Vaughan TL, Risch HA, Gammon MD, Lissowska J, Weck MN, Raum E, Müller H, Illig T, Klopp N, Dawson A, McColl KE, Brenner H, Chow WH, El-Omar EM. Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals. Gastroenterology 2011;140:435-41.
• Wild B, Lechner S, Herzog W, Maatouk I, Wesche D, Raum E, Müller H, Brenner H, Slaets J, Huyse F, Söllner W Reliable integrative assessment of health care needs in elderly persons: the INTERMED for the Elderly (IM-E). J Psychosom Res 2011;70:169-78.
• Emerging Risk Factors Collaboration, Seshasai SR, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, Whincup PH, Mukamal KJ, Gillum RF, Holme I, Njølstad I, Fletcher A, Nilsson P, Lewington S, Collins R, Gudnason V, Thompson SG, Sattar N, Selvin E, Hu FB, Danesh J. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 2011;364:829-41.  
• Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Meta-analysis: circulating vitamin D and ovarian cancer risk. Gynecol Oncol 2011;121:369-75.
• Raum E, Küpper-Nybelen J, Lamerz A, Hebebrand J, Herpertz-Dahlmann B, Brenner H. Tobacco smoke exposure before, during and after pregnancy and risk of overweight at age 6. Obesity 2011;19:2411-7.
• Schöttker B, Raum E, Rothenbacher D, Müller H, Brenner H. Prognostic value of haemoglobin A1c and fasting plasma glucose for incident diabetes and implications for screening. Eur J Epidemiol. 2011;26:779-87.
• Krämer HU, Schöttker B, Raum E, Brenner H. Type 2 diabetes mellitus and colorectal cancer: meta-analysis on sex-specific differences. Eur J Cancer. 2012;48:1269-82.
• Breitling LP, Müller H, Illig T, Rujescu D, Winterer G, Dahmen N, Nitz B, Raum E, Rothenbacher D, Brenner. Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers. Pharmacogenomics 2011;12:1099-106. 
• Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Meta-analysis: serum vitamin D and colorectal adenoma risk. Prev Med. 2011;53:10-6.
• Frank B, Müller H, Weck MN, Klopp N, Illig T, Raum E, Brenner H. DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study.BMC Cancer. 2011 Oct 11;11:440.
• Müller H, Raum E, Brenner H. Epidemiological aging research in a national and international context. Z Gerontol Geriat 2011;44 Suppl 2:28-31.
• Saum KU; Müller H, Raum E, Brenner. Survey of multimorbidity and frailty in old age in the context of epidemiological studies. Z Gerontol Geriat 2011;44 Suppl 2:31-32.
• Frank B, Weck MN, Müller H, Klopp N, Illig T, Raum E, Brenner H. Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis. Eur J Cancer 2012; 48:114-20.
• Maatouk I, Wild B, Wesche D, Herzog W, Raum E, Müller H, Rothenbacher D, Stegmaier C, Schellberg D, Brenner H.Temporal predictors of health-related quality of life in elderly people with diabetes: results of a german cohort study. PLoS One. 2012;7(1):e31088.
• Wild B, Herzog W, Schellberg D, Lechner S, Niehoff D, Brenner H, Rothenbacher D, Stegmaier C, Raum E. Association between the prevalence of depression and age in a large representative German sample of people aged 53 to 80 years. Int J Geriatr Psychiatry 2012;27:375-81.
• Breitling LP, Perna L, Müller H, Raum E, Kliegel M, Brenner H. Vitamin D and cognitive functioning in the elderly population in Germany. Exp Gerontol. 2012;47:122-7.
• Raum E, Krämer HU, Rüter G, Rothenbacher D, Rosemann T, Szecsenyi J, Brenner H. Medication non-adherence and poor glycaemic control in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2012;97:377-84. 
• Perna L, Haug U, Schöttker B, Müller H, Raum E, Jansen EH, Brenner H. Public health implications of standardized 25-hydroxyvitamin D levels: a decrease in the prevalence of vitamin D deficiency among older women in Germany. Prev Med 2012;55:228-32.
• Krämer HU, Müller H, Stegmaier C, Rothenbacher D, Raum E, Brenner H. Type 2 diabetes mellitus and gender-specific risk for colorectal neoplasia. Eur J Epidemiol  2012;27:341-7.
• Krämer HU, Rüter G, Schöttker B, Rothenbacher D, Rosemann T, Szecsenyi J, Brenner H, Raum E. Gender differences in healthcare utilization of patients with diabetes. Am J Manag Care 2012;18:362-9.
• Krämer HU, Raum E, Rüter G, Schöttker B, Rothenbacher D, Rosemann T, Szecsenyi J, Brenner H. Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study. Cardiovasc Diabetol  2012 Jul ;11:88.
• Goetz K, Szecsenyi J, Campbell S, Rosemann T, Rueter G, Raum E, Brenner H, Miksch A. The importance of social support for people with type 2 diabetes - a qualitative study with general practitioners, practice nurses and patients. Psychosoc Med. 2012;9:Doc02.
• Wild B, Herzog W, Lechner S, Niehoff D, Brenner H, Müller H, Rothenbacher D, Stegmaier C, Raum E. Gender-specific temporal and cross-sectional associations between BMI-class and symptoms of depression in the elderly. J Psychosom Res 2012;72:376-82.
• Saum KU, Müller H, Stegmaier C, Hauer K, Raum E, Brenner H. Development and evaluation of a modification of the Fried frailty criteria using population-independent cutpoints. J Am Geriatr Soc 2012;60:2110-5.
• Perna L, Felix JF, Breitling LP, Haug U, Raum E, Burwinkel B, Schöttker B, Brenner H. Genetic variations in the vitamin d binding protein and season-specific levels of vitamin d among older adults. Epidemiology 2013;104-9.

Book chapters, books and reports

• Raum E, Arabin A, Schlaud M, Walter U, Schwartz FW. The influence of smoking, pregravid nutritional status, and weight gain on intrauterine child development: Results of a study in West and East Germany. In German Society for Public Health (ed.): public health research in Germany. Hans Huber Publishers. Bern 1999: 140-145.
• Raum E, Perleth M. Methods of meta-analyses of diagnostic accuracy studies. HTA report. Ed: German Agency for Health Technology Assessment of the German Institute for Medical Documentation and Information. Medicombooks, Niebüll, 2003.
• Raum E., Lietzau S. Possibilities of health prevention in women in the second half of life (55 years and older). Reanalysis of data sets obtained in a large epidemiological study - the ESTHER study. Report prepared for the Federal Ministry of Health. 2005.